2. Signaling Pathways
  3. Neuronal Signaling
    Protein Tyrosine Kinase/RTK
  4. Trk Receptor
  5. Trk Isoform

Trk

Trk receptors are neurotrophin receptor tyrosine kinases that mediate neurotrophin-dependent neuronal survival, differentiation, development, and broader physiological effects[1][2]. Mechanistically, activated Trk receptors signal through phosphotyrosine-mediated pathways, including Shc, PLCγ, PI3K, Ras/MAPK, and Akt, thereby linking ligand binding to transcriptional and survival responses[1][3][4]. In experimental models, NGF-activated TrkA forms internalized signaling vesicles that may support retrograde neurotrophin signaling in neurons[5]. In disease models, Trk signaling contributes to cancer biology: TrkA is overexpressed in oesophageal squamous cell carcinoma, p-TrkA is proposed as a potential epithelial ovarian cancer marker, and Trk inhibition reduces lymphoma cell survival or proliferation[6][7][8]. Compared with related isoforms, TrkA primarily mediates NGF responses, TrkB responds strongly to BDNF and also NT-3, whereas TrkC functions as a high-affinity NT-3 receptor that does not bind NGF or BDNF[9][10]. This isoform distinction supports research designs that select ligands, receptor readouts, and inhibitors according to TrkA, TrkB, or TrkC biology rather than treating Trk as a single target class[9][10].

References:

Trk Related Products (3):

Cat. No. Product Name Effect Purity
  • HY-107362
    CH7057288
    		Inhibitor 99.73%
    CH7057288 is a potent and selective TRK inhibitor. CH7057288 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • HY-174330A
    TRK-IN-31 hydrochloride
    		Inhibitor
    TRK-IN-31 hydrochloride is an orally active TRK inhibitor with an IC50 of 1.8 nM. TRK-IN-31 hydrochloride has superior antiproliferative activity in the Ba/F3-MPRIP-TRKAG667C cells, and potently inhibits TRK kinase activity with high selectivity. TRK-IN-31 hydrochloride significantly inhibits tumor growth in Ba/F3-MPRIP-TRKAG667C subcutaneous tumor mice model.
  • HY-174330
    TRK-IN-31
    		Inhibitor
    TRK-IN-31 is an orally active TRK inhibitor with an IC50 of 1.8 nM. TRK-IN-31 has superior antiproliferative activity in the Ba/F3-MPRIP-TRKAG667C cells, and potently inhibits TRK kinase activity with high selectivity. TRK-IN-31 significantly inhibits tumor growth in Ba/F3-MPRIP-TRKAG667C subcutaneous tumor mice model.
Cat. No. Product Name / Synonyms Application Reactivity